Monocarboxylate transporter 11 (IPR030769)

Short name: MCT11

Overlapping homologous superfamilies

Family relationships


Monocarboxylate transporter 11 (MCT11), also known as SLC16A11, belongs to the MCT family. The function of MCT11 is not clear. Sequence variants in SLC16A11 are a risk factor for type 2 diabetes, indicating a a possible role in triacylglycerol metabolism [PMID: 24390345].

Monocarboxylate transporters (MCTs) catalyse the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane [PMID: 9425115, PMID: 22131303]. All of the MCT family (also known as SLC16 solute carrier family) members share conserved sequence motifs. They are are predicted to have 12-transmembrane helices (TMs) with intracellular C and N termini and a large cytosolic loop between TMs 6 and 7 [PMID: 22131303].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.