Pathways & interactions
Monocarboxylate transporter 11 (IPR030769)
Short name: MCT11
Overlapping homologous superfamilies
- MFS transporter superfamily (IPR036259)
- Major facilitator superfamily (IPR011701)
- Monocarboxylate transporter 11 (IPR030769)
Monocarboxylate transporter 11 (MCT11), also known as SLC16A11, belongs to the MCT family. The function of MCT11 is not clear. Sequence variants in SLC16A11 are a risk factor for type 2 diabetes, indicating a a possible role in triacylglycerol metabolism [PMID: 24390345].
Monocarboxylate transporters (MCTs) catalyse the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane [PMID: 9425115, PMID: 22131303]. All of the MCT family (also known as SLC16 solute carrier family) members share conserved sequence motifs. They are are predicted to have 12-transmembrane helices (TMs) with intracellular C and N termini and a large cytosolic loop between TMs 6 and 7 [PMID: 22131303].
- PTHR11360:SF80 (PTHR11360:SF80)