Pathways & interactions
Monocarboxylate transporter 9 (IPR030767)
Short name: MCT9
Overlapping homologous superfamilies
- Major facilitator superfamily (IPR011701)
- Monocarboxylate transporter 9 (IPR030767)
Monocarboxylate transporter 9 (MCT9), also known as SLC16A9, belongs to the MCT family. The function of MCT9 is not clear. A variant in human MCT9 gene has been linked to renal overload gout [PMID: 23990105]. This entry also includes monocarboxylate transporter 14 (MCT14).
Monocarboxylate transporters (MCTs) catalyse the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane [PMID: 9425115, PMID: 22131303]. All of the MCT family (also known as SLC16 solute carrier family) members share conserved sequence motifs. They are are predicted to have 12-transmembrane helices (TMs) with intracellular C and N termini and a large cytosolic loop between TMs 6 and 7 [PMID: 22131303].
- PTHR11360:SF158 (PTHR11360:SF158)