Monocarboxylate transporter 10 (IPR030762)
Short name: MCT10
Overlapping homologous superfamilies
- MFS transporter superfamily (IPR036259)
- Major facilitator superfamily (IPR011701)
- Monocarboxylate transporter 10 (IPR030762)
Monocarboxylate transporter 10 (MCT10), also known as SLC16A10 or TAT1, belongs to the MCT family. It transports aromatic amino acids (phenylalanine, tyrosine, and tryptophan) in a sodium and proton independent manner [PMID: 20660303]. It has been shown to transport thyroid hormone (TH) [PMID: 18337592, PMID: 24248460].
Monocarboxylate transporters (MCTs) catalyse the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane [PMID: 9425115, PMID: 22131303]. All of the MCT family (also known as SLC16 solute carrier family) members share conserved sequence motifs. They are are predicted to have 12-transmembrane helices (TMs) with intracellular C and N termini and a large cytosolic loop between TMs 6 and 7 [PMID: 22131303].
- PTHR11360:SF119 (PTHR11360:SF119)