Family

Monocarboxylate transporter 10 (IPR030762)

Short name: MCT10

Overlapping homologous superfamilies

Family relationships

Description

Monocarboxylate transporter 10 (MCT10), also known as SLC16A10 or TAT1, belongs to the MCT family. It transports aromatic amino acids (phenylalanine, tyrosine, and tryptophan) in a sodium and proton independent manner [PMID: 20660303]. It has been shown to transport thyroid hormone (TH) [PMID: 18337592, PMID: 24248460].

Monocarboxylate transporters (MCTs) catalyse the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane [PMID: 9425115, PMID: 22131303]. All of the MCT family (also known as SLC16 solute carrier family) members share conserved sequence motifs. They are are predicted to have 12-transmembrane helices (TMs) with intracellular C and N termini and a large cytosolic loop between TMs 6 and 7 [PMID: 22131303].

GO terms

Biological Process

GO:0055085 transmembrane transport

Molecular Function

GO:0015173 aromatic amino acid transmembrane transporter activity
GO:0015349 thyroid hormone transmembrane transporter activity

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER