Monocarboxylate transporter 8 (IPR030761)

Short name: MCT8

Overlapping homologous superfamilies

Family relationships


Monocarboxylate transporter 8 (MCT8), also known as SLC16A2, belongs to the MCT family. It is a thyroid hormone transporter [PMID: 12871948]. Mutations in the MCT8 gene is associated with psychomotor retardation [PMID: 15488219, PMID: 18636565].

Monocarboxylate transporters (MCTs) catalyse the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane [PMID: 9425115, PMID: 22131303]. All of the MCT family (also known as SLC16 solute carrier family) members share conserved sequence motifs. They are are predicted to have 12-transmembrane helices (TMs) with intracellular C and N termini and a large cytosolic loop between TMs 6 and 7 [PMID: 22131303].

GO terms

Biological Process

GO:0070327 thyroid hormone transport

Molecular Function

GO:0015349 thyroid hormone transmembrane transporter activity

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.