Monocarboxylate transporter 6 (IPR030760)

Short name: MCT6

Overlapping homologous superfamilies

Family relationships


Monocarboxylate transporter 6 (MCT6), also known as SLC16A5, belongs to the MCT family. MCT6 transports various drugs such as probenecid and nateglinide. However, neither L-lactic acid nor L-tryptophan, typical substrates of other MCT isoforms, is transported by MCT6 [PMID: 16174808, PMID: 23935065].

Monocarboxylate transporters (MCTs) catalyse the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane [PMID: 9425115, PMID: 22131303]. All of the MCT family (also known as SLC16 solute carrier family) members share conserved sequence motifs. They are are predicted to have 12-transmembrane helices (TMs) with intracellular C and N termini and a large cytosolic loop between TMs 6 and 7 [PMID: 22131303].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.