Monocarboxylate transporter 3 (IPR030759)

Short name: MCT3

Overlapping homologous superfamilies


Family relationships


Monocarboxylate transporter 3 (MCT3), also known as SLC16A8, belongs to the MCT family. It may play an important role in facilitating the transport of glycolytically derived lactic acid out of the retina [PMID: 22131303].

Monocarboxylate transporters (MCTs) catalyse the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane [PMID: 9425115, PMID: 22131303]. All of the MCT family (also known as SLC16 solute carrier family) members share conserved sequence motifs. They are are predicted to have 12-transmembrane helices (TMs) with intracellular C and N termini and a large cytosolic loop between TMs 6 and 7. Four mammalian isoforms, MCTs 1-4, have been identified, each with distinct substrate and inhibitor affinities [PMID: 22131303]. MCT1-4 have been linked to cancer maintenance and aggressiveness [PMID: 22407107].

GO terms

Biological Process

GO:0015718 monocarboxylic acid transport

Molecular Function

GO:0015129 lactate transmembrane transporter activity
GO:0008028 monocarboxylic acid transmembrane transporter activity

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.