Monocarboxylate transporter 1 (IPR030757)

Short name: MCT1

Family relationships


Monocarboxylate transporter 1 (MCT1), also known as SLC16A1, belongs to the MCT family. It facilitates unidirectional proton-linked transport of L-lactate across the plasma membrane [PMID: 22131303, PMID: 7980443]. Several natural occurring substrates for MCT1 have been found, including L-lactate, pyruvate, beta-hydroxybutyrate, and acetoacetate [PMID: 22131303]. Inhibition of MCT1 during T lymphocyte activation results in selective and profound inhibition of the extremely rapid phase of T cell division essential for an effective immune response. Therefore, MCT1 has been used as a target for immunosuppressive therapy [PMID: 16370372, PMID: 16455256].

Monocarboxylate transporters (MCTs) catalyse the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane [PMID: 9425115, PMID: 22131303]. All of the MCT family (also known as SLC16 solute carrier family) members share conserved sequence motifs. They are are predicted to have 12-transmembrane helices (TMs) with intracellular C and N termini and a large cytosolic loop between TMs 6 and 7. Four mammalian isoforms, MCTs 1-4, have been identified, each with distinct substrate and inhibitor affinities [PMID: 22131303]. MCT1-4 have been linked to cancer maintenance and aggressiveness [PMID: 22407107].

GO terms

Biological Process

GO:0015718 monocarboxylic acid transport

Molecular Function

GO:0015129 lactate transmembrane transporter activity
GO:0008028 monocarboxylic acid transmembrane transporter activity

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.