Family

von Willebrand factor A domain-containing protein 2 (IPR030755)

Short name: VWA2

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

von Willebrand factor A domain-containing protein 2 (VWA2 protein) or AMACO is an extracellular matrix protein containing VWA-like domains related to those in matrilins and collagens. The protein consists of a signal peptide sequence, an N-terminal VWA domain connected to two additional tandem VWA domains by a cysteine-rich sequence and an epidermal growth factor (EGF)-like domain, and a C terminus made up of another EGF-like domain followed by a unique sequence present in mouse, but absent in human [PMID: 14506275]. VWA2 protein is a component of the Fraser complex (FC). FC is believed to stabilise the basement membrane, which is a non-celular matrix that separates epithelium, mesothelium and endothelium from the underlying connective tissue [PMID: 24232570, PMID: 24732331].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005604 basement membrane
GO:0005615 extracellular space

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER