Ral guanine nucleotide dissociation stimulator-like 3 (IPR030750)

Short name: RGL3

Overlapping homologous superfamilies

Family relationships



RGL3 (RalGDS-like 3) belongs to the Ral GDP dissociation stimulator (RalGDS) family [PMID: 10760592]. RGL3 functions as an exchange factor for Ral and may serve as a downstream effector for both Rit and Ras [PMID: 10869344, PMID: 11313946].

RalGDS family members can act both as Ras effectors and as guanine nucleotide exchange factors (GEFs) for Ral. They act downstream of Ras and bind to the GTP-bound active form of Ras or Ras family members. They also promote the GDP to GTP exchange for Ral small GTPase, member of the Ras family [PMID: 9099691]. Due to their double action, the RalGDS proteins bridge Ras and Ral [PMID: 20478380].

GO terms

Biological Process

GO:0043547 positive regulation of GTPase activity
GO:0007264 small GTPase mediated signal transduction

Molecular Function

GO:0008321 Ral guanyl-nucleotide exchange factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.