Ral guanine nucleotide dissociation stimulator-like 1 (IPR030748)

Short name: RGL1

Overlapping homologous superfamilies

Family relationships



RGL (RalGDS-like 1) belongs to the Ral GDP dissociation stimulator (RalGDS) family [PMID: 10760592]. It is a binding partner for small G-proteins. The function of RGL1 is not clear.

RalGDS family members can act both as Ras effectors and as guanine nucleotide exchange factors (GEFs) for Ral. They act downstream of Ras and bind to the GTP-bound active form of Ras or Ras family members. They also promote the GDP to GTP exchange for Ral small GTPase, member of the Ras family [PMID: 9099691]. Due to their double action, the RalGDS proteins bridge Ras and Ral [PMID: 20478380].

GO terms

Biological Process

GO:0007264 small GTPase mediated signal transduction

Molecular Function

GO:0008321 Ral guanyl-nucleotide exchange factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.