IQ motif and SEC7 domain-containing protein 1 (IPR030737)

Short name: IQSEC1

Overlapping homologous superfamilies


Family relationships



IQ motif and SEC7 domain-containing protein 1 (IQSEC1), also known as Arf-GEP100 or BRAG2, is a GEF (guanine nucleotide exchange factor) for Arf6 GTPase. In addition to Arf6, endogenous BRAG2 also activates the class II Arfs, Arf4 and Arf5. It acts at clathrin-coated pits to promote integrin internalization by activating Arf [PMID: 16461286, PMID: 22815487]. It regulates phagocytosis of monocytic phagocytes in an ARF6-dependent process [PMID: 20601426] and is involved in the apoptotic cell death of monocytic phagocytes [PMID: 16877676].

GO terms

Biological Process

GO:0043547 positive regulation of GTPase activity
GO:0032012 regulation of ARF protein signal transduction

Molecular Function

GO:0005086 ARF guanyl-nucleotide exchange factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.