Protocadherin-15 (IPR030718)

Short name: Protocadherin-15

Overlapping homologous superfamilies


Family relationships



Protocadherin-15 (Pcdh15) belongs to the epsilon subfamily of nonclustered protocadherins. It is a component of the tip-links, the extracellular filaments that connect the tips of stereocilia and gate hair cell mechano-electrical transduction channels in the inner ear [PMID: 24940003]. Pcdh15 interacts with transmembrane channel-like proteins TMC1 and TMC2, which have been implicated in mechanotransduction in mammalian hair cells [PMID: 25114259]. Mutations in genes coding for Pcdh15 cause deafness in both mice and humans [PMID: 15537665, PMID: 16799054]. Pcdh15 plays an important role in hair-bundle morphogenesis [PMID: 15811708].

The cadherin family consists of a large group of cell adhesion proteins. It can be classified into three subfamilies: classical cadherins, desmosomal cadherins and protocadherins (PCDHs). Based on the genomic structure, the PCDH family can be divided into two groups, clustered PCDHs and non-clustered PCDHs. Non-clustered PCDHs can be further classified into three subgroups: delta1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), delta2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and epsilon (PCDH15, PCDH16, PCDH21 and MUCDHL). Non-clustered PCDHs are expressed predominantly in the nervous system and have spatiotemporally diverse expression patterns [PMID: 21173574].

GO terms

Biological Process

GO:0007155 cell adhesion
GO:0048839 inner ear development
GO:0007605 sensory perception of sound

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0032420 stereocilium

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.