Family

Dedicator of cytokinesis protein 1/5 (IPR030717)

Short name: DOCK1/DOCK5

Overlapping homologous superfamilies

None.

Family relationships

Description

DOCK1 (also known as DOCK180) is the prototypic member of the DOCK protein family. DOCK1 forms complex with ELMO proteins. The DOCK1/ELMO complex mediates the activation of Rac at the cell leading edge for lamellipodia formation, which further promotes cell spreading and migration [PMID: 14638695]. DOCK1 can also bind to ankirin domain-repeat protein 28 (ANKRD28), which regulates focal adhesion formation [PMID: 19118547]. DOCK1 has been linked to cancer growth and invasion [PMID: 23591873, PMID: 25468898]. DOCK5, along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on collagen IV [PMID: 19004829].

DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases [PMID: 12432077]. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis. The N-terminal SH3 domain of the DOCK proteins functions as an inhibitor of GEF, which can be relieved upon its binding to the ELMO1-3 adaptor proteins, after their binding to active RhoG at the plasma membrane [PMID: 25022758, PMID: 15723800]. DOCK family proteins are categorised into four subfamilies based on their sequence homology: DOCK-A subfamily (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11) [PMID: 12432077].

GO terms

Biological Process

GO:0016477 cell migration
GO:0007264 small GTPase mediated signal transduction

Molecular Function

GO:0005096 GTPase activator activity
GO:0005085 guanyl-nucleotide exchange factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER