Engulfment and cell motility protein 1 (IPR030715)

Short name: ELMO1

Overlapping homologous superfamilies


Family relationships



This entry represents engulfment and cell motility protein 1 (ELMO1) from vertebrates. ELMO1 is a scaffolding component of the Elmo-Dock complex. It interacts with DOCK180, which is essential for activation of Rac GTPase-dependent biological processes. Its C-terminal pleckstrin homology (PH) domain mediates direct interaction to DOCK180 and is critical in Rac signalling [PMID: 18768751]. ELMO1 also interacts with DOCK2 and plays a role in controlling DOCK2 levels and DOCK2-dependent T cell migration in primary lymphocytes [PMID: 12829596, PMID: 24821968]. ELMO1 has been linked to invasive phenotype of cancer cells [PMID: 24819662, PMID: 25360637, PMID: 23591873].

ELMO 1-3 are orthologues of the Caenorhabditis elegans ced-12, which is required for the engulfment of dying cells and cell migration [PMID: 11595183]. They are cytoplasmic adaptor proteins that interact with DOCK family guanine nucleotide exchange factors (GEFs) to promote activation of the small GTPase Rac [PMID: 24821968]. ELMO proteins interact with the SH3-domain of DOCKs via an SH3-binding site to enhance the GEF activity of DOCKs. Regulatory GTPases in the Ras superfamily employ a cycle of alternating GTP binding and hydrolysis, controlled by GEFs and GTPase-activating proteins (GAPs), as essential features of their actions in cells [PMID: 11595183, PMID: 17452337].

GO terms

Biological Process

GO:0030036 actin cytoskeleton organization
GO:0016477 cell migration
GO:0006909 phagocytosis

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.