Protocadherin-18 (IPR030714)

Short name: Protocadherin-18

Overlapping homologous superfamilies


Family relationships



Protocadherin-18 (Pcdh18) belongs to the delta-2 subfamily of nonclustered protocadherins (comprising protocadherin-8, -10, -17, -18, and -19) [PMID: 15905963]. Zebrafish has two Pcdh18 isoforms, Pcdh18a and Pcdh18b. Pcdh18a has a role in cell adhesion and migration [PMID: 18468594], whereas Pcdh18b interacts with Nap1, an important regulator of actin dynamics, to control motor axon growth and arborisation in primary motoneurons [PMID: 24371087]. In mouse, Pcdh18 interacts with Disabled-1 (Dab1) and may play a role during brain development [PMID: 11716507].

The cadherin family consists of a large group of cell adhesion proteins. It can be classified into three subfamilies: classical cadherins, desmosomal cadherins and protocadherins (PCDHs). Based on the genomic structure, the PCDH family can be divided into two groups, clustered PCDHs and non-clustered PCDHs. Non-clustered PCDHs can be further classified into three subgroups: delta1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), delta2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and epsilon (PCDH15, PCDH16, PCDH21 and MUCDHL). Non-clustered PCDHs are expressed predominantly in the nervous system and have spatiotemporally diverse expression patterns [PMID: 21173574].

GO terms

Biological Process

GO:0007155 cell adhesion
GO:0007399 nervous system development

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.