Protocadherin-17 (IPR030709)

Short name: Protocadherin-17

Overlapping homologous superfamilies


Family relationships



Protocadherin-17 (Pcdh17) belongs to the delta-2 subfamily of nonclustered protocadherins. The non-clustered PCDHs appear to have homophilic/heterophilc cell-cell adhesion properties [PMID: 21173574], and the delta-2 subfamily (comprising protocadherin-8, -10, -17, -18, and -19) is widely expressed in the nervous system [PMID: 19616130, PMID: 15905963]. Pcdh17 mediates collective axon extension in amygdala neurons [PMID: 25199687], regulates presynaptic assembly in corticobasal ganglia circuits [PMID: 23684785], and is involved in brain vascular development [PMID: 19189440]. In addition, it has been shown to have a role in the formation of the zebrafish retina [PMID: 22927092] and to act as a tumour suppressor [PMID: 22926751, PMID: 20200074].

The cadherin family consists of a large group of cell adhesion proteins. It can be classified into three subfamilies: classical cadherins, desmosomal cadherins and protocadherins (PCDHs). Based on the genomic structure, the PCDH family can be divided into two groups, clustered PCDHs and non-clustered PCDHs. Non-clustered PCDHs can be further classified into three subgroups: delta1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), delta2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and epsilon (PCDH15, PCDH16, PCDH21 and MUCDHL). Non-clustered PCDHs are expressed predominantly in the nervous system and have spatiotemporally diverse expression patterns [PMID: 21173574].

GO terms

Biological Process

GO:0007155 cell adhesion

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005886 plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.