Histone deacetylase 5 (IPR030703)

Short name: Histone_deacetylase_5

Overlapping homologous superfamilies


Family relationships


Histone deacetylases (HDACs) modulate the acetylation level of histone and non-histone proteins to regulate chromatin structure and gene expression. Histone deacetylase 5 (HDAC5) undergoes signal-dependent translocation between the nucleus and cytoplasm, which is regulated in part by calcium/calmodulin-dependent kinase (CaMK)-mediated phosphorylation. HDAC5 and its intracellular translocation are key effectors of multiple pathways that regulate neuronal cell apoptosis [PMID: 25661252]. HDAC5 has been identified as a inflammatory mediator in rheumatoid arthritis, as its expression is suppressed by inflammatory cytokines which leads to activation of fibroblast-like synoviocytes [PMID: 25452308, PMID: 25512013].

GO terms

Biological Process

GO:0016575 histone deacetylation
GO:0040029 regulation of gene expression, epigenetic

Molecular Function

GO:0004407 histone deacetylase activity

Cellular Component

GO:0005737 cytoplasm
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.