Ras-related protein Rab14 (IPR030702)

Short name: Rab14

Overlapping homologous superfamilies

Family relationships

  • Small GTPase (IPR001806)
    • Ras-related protein Rab14 (IPR030702)


Ras-related protein Rab14 is a small GTPase that mediates endocytic recycling and functions in phagosome maturation [PMID: 22595666, PMID: 22569897]. Rab14 and its exchange factor FAM116 regulates the specific endocytic transport of ADAM10 and thereby N-cadherin shedding and cell motility [PMID: 22595666, PMID: 22595670]. Rab14 regulates claudin-2 trafficking, which is required for epithelial morphogenesis [PMID: 24694596]. It regulates apical targeting in polarised epithelial cells [PMID: 18429929]. Rab14 also regulates the interaction of phagosomes with early endocytic compartments and the maturation of macrophage phagosomes containing the fungal pathogen Candida albicans [PMID: 25644001]. Drosophila Rab14 mediates phagocytosis in the immune response to Staphylococcus aureus [PMID: 24119134].

GO terms

Biological Process

GO:0006895 Golgi to endosome transport
GO:0042742 defense response to bacterium
GO:0032456 endocytic recycling
GO:0090382 phagosome maturation

Molecular Function

GO:0005525 GTP binding
GO:0003924 GTPase activity

Cellular Component

GO:0045335 phagocytic vesicle
GO:0055037 recycling endosome
GO:0005802 trans-Golgi network

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.