Family

Arginine-tRNA-protein transferase (IPR030700)

Short name: Arg-tRNA_Trfase

Family relationships

Description

Arginine-tRNA-protein transferase catalyses the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway of protein degradation by conjugating a destabilising amino acid to the N-terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis [PMID: 9858543]. In Saccharomyces cerevisiae, Cys20, 23, 94 and/or 95 are thought to be important for activity [PMID: 7495814]. Of these, only Cys 94 appears to be completely conserved in this family.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER