Family

N-end rule aminoacyl transferase (IPR030700)

Short name: N-end_Aminoacyl_Trfase

Overlapping homologous superfamilies

Family relationships

Description

This entry represents a family of aminoacyl-transferases that includes prokaryotic aspartate/glutamate leucyltransferase, and eukaryotic arginine-tRNA-protein transferase.

Arginine-tRNA-protein transferase catalyses the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway of protein degradation by conjugating a destabilising amino acid to the N-terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis [PMID: 9858543]. In Saccharomyces cerevisiae, Cys20, 23, 94 and/or 95 are thought to be important for activity [PMID: 7495814]. Of these, only Cys 94 appears to be completely conserved in this family.

Aspartate/glutamate leucyltransferase (also known as bacterial protein transferase or Bpt) functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate. This protein shows sequence similarity to the eukaryotic N-end rule pathway component arginyl-transferase Ate1 [PMID: 16492767].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER