Family

Ras-related protein Rab29/Rab38/Rab32 (IPR030697)

Short name: Rab29/Rab38/Rab32

Overlapping homologous superfamilies

Family relationships

Description

This entry represents the Rab29/Rab38/Rab32 subfamily. They are members of the Rab family of small GTPases. Human Rab32 was first identified in platelets but it is expressed in a variety of cell types, where it functions as an A-kinase anchoring protein (AKAP) [PMID: 12186851]. Rab32 and closely related Rab38 are functionally redundant regulators of melanosomal protein trafficking and melanocyte pigmentation [PMID: 17043139, PMID: 26818140].

Ras-related protein Rab29 (also known as RAB7L) is related to Rab32 and Rab38. Rab29 regulates phagocytosis and traffic from the Golgi to the lysosome [PMID: 24788816]. It is associated with trans-Golgi network (TGN) and is essential for maintaining the integrity of the TGN. Together with LRRK2, it plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner [PMID: 24788816].

Rab29, Rab32 and Rab38 can be cleaved by GtgE, which is an effector protein from Salmonella Typhimurium that modulates trafficking of the Salmonella-containing vacuole (SCV) [PMID: 24531472]. By targeting these GTPases, GtgE allows survival of the pathogen by preventing the delivery of antimicrobial factors to the SCV [PMID: 22042847].

GO terms

Biological Process

GO:0016192 vesicle-mediated transport

Molecular Function

GO:0005525 GTP binding
GO:0003924 GTPase activity

Cellular Component

GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0031982 vesicle

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD