Pathways & interactions
Protein NDRG4 (IPR030695)
Short name: NDRG4
Overlapping homologous superfamilies
- Alpha/Beta hydrolase fold (IPR029058)
- NDRG (IPR004142)
- Protein NDRG4 (IPR030695)
N-myc downstream regulated gene (NDRG) family members are characterised by an alpha/beta hydrolase-fold motif. NDRG proteins may function as tumour suppressors and may also play important roles in the development of neurological and electrophysiological diseases [PMID: 21247902, PMID: 20667976].
This entry represents NDRG4. It is expressed in brain and heart [PMID: 11352569]. NDRG4 is required for normal myocyte proliferation during early cardiac development in zebrafish [PMID: 18407257]. It plays a role in neurite outgrowth and has an influence on nerve growth factor (NGF)-stimulated transcription factor AP-1 activation [PMID: 11978393]. It has been linked to prolongation of the QT interval, a cardiac electrophysiological disorder that might predispose to sudden cardiac death and ventricular arrhythmias [PMID: 22912591, PMID: 20667976].
- PTHR11034:SF21 (PTHR11034:SF21)