Pathways & interactions
Protein NDRG3 (IPR030692)
Short name: NDRG3
Overlapping homologous superfamilies
- Alpha/Beta hydrolase fold (IPR029058)
- NDRG (IPR004142)
- Protein NDRG3 (IPR030692)
N-myc downstream regulated gene (NDRG) family members are characterised by an alpha/beta hydrolase-fold motif. NDRG proteins may function as tumour suppressors and may also play important roles in the development of neurological and electrophysiological diseases [PMID: 21247902, PMID: 20667976].
This entry represents NDRG3. The function of NDRG3 is not clear. NDRG3 is highly expressed in the testis, ovary, prostate, spinal cord and thymus rudiment [PMID: 23725756]. Its overexpression increases growth rate and migration of the prostate cancer cells and promotes tumour growth in nude mice [PMID: 20667976].
- PTHR11034:SF20 (PTHR11034:SF20)