Protein NDRG3 (IPR030692)

Short name: NDRG3

Overlapping homologous superfamilies

Family relationships

  • NDRG (IPR004142)
    • Protein NDRG3 (IPR030692)


N-myc downstream regulated gene (NDRG) family members are characterised by an alpha/beta hydrolase-fold motif. NDRG proteins may function as tumour suppressors and may also play important roles in the development of neurological and electrophysiological diseases [PMID: 21247902, PMID: 20667976].

This entry represents NDRG3. The function of NDRG3 is not clear. NDRG3 is highly expressed in the testis, ovary, prostate, spinal cord and thymus rudiment [PMID: 23725756]. Its overexpression increases growth rate and migration of the prostate cancer cells and promotes tumour growth in nude mice [PMID: 20667976].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.