Sterol O-acyltransferase, metazoa (IPR030687)

Short name: Sterol_acyltranf_meta

Overlapping homologous superfamilies


Family relationships


Sterol O-acyltransferase 1 (SOAT1; also known as ACAT1) and sterol O-acyltransferase 2 (SOAT2; also known as ACAT2) both play a role in the formation of fatty acid-cholesterol esters [PMID: 9756920]. Cholesterol esters are less soluble in membranes than cholesterol and accumulate in atherosclerotic lesions, making ACAT inhibitors a pharmacological target against atherosclerosis [PMID: 16518538, PMID: 25450374]. SOAT1 is present in steroidogenic tissues, kidneys, sebaceous glands and macrophages. SOAT2 is expressed predominantly in the liver and small intestine [PMID: 9756919, PMID: 11108732].

GO terms

Biological Process

GO:0034435 cholesterol esterification
GO:0042632 cholesterol homeostasis

Molecular Function

GO:0034736 cholesterol O-acyltransferase activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.