Family

Lactotransferrin (IPR030684)

Short name: Lactotransferrin

Family relationships

Description

Lactotransferrin or lactoferrin (Lf) is an iron binding glycoprotein that exists in body secretions as a line of natural defence and plays an important role in defence against pathogenic bacteria, fungi, protozoa and viruses. It has multiple activities ranging from the intestinal iron absorption, intestinal cell growth, regulation of myelopoiesis and immune responses [PMID: 18268518]. Bovine Lf also possesses potent anti-cancer activities [PMID: 23016584]. Lf has been shown to be a serine peptidase [PMID: 12535064] and belongs to MEROPS family S60.

GO terms

Biological Process

GO:0019731 antibacterial humoral response
GO:0019732 antifungal humoral response
GO:0001817 regulation of cytokine production

Molecular Function

GO:0005506 iron ion binding
GO:0004252 serine-type endopeptidase activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF
PANTHER