Pyrophosphatase, GppA/Ppx-type (IPR030673)

Short name: PyroPPase_GppA_Ppx

Overlapping homologous superfamilies


Family relationships


This entry includes guanosine-5'-triphosphate,3'-diphosphate pyrophosphatases (also known as pppGpp-5'-phosphohydrolases) and exopolyphosphatases.

Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (GppA), also known as guanosine pentaphosphate phosphohydrolase, catalyses the conversion of pppGpp to ppGpp.

Exopolyphosphatases (Ppx) is involved in the degradation of inorganic polyphosphates [PMID: 8380170] and belongs to the same family as the guanosine pentaphosphate phosphatase [PMID: 8212131].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.