Adenylate cyclase (IPR030672)

Short name: Adcy

Overlapping homologous superfamilies


Family relationships



This entry represents a group of adenylate cyclases (ACs) from animals, including adenylate cyclase type 1-8 from humans.

Cyclic AMP (cAMP) is a ubiquitous signalling molecule which mediates many cellular processes by activating cAMP-dependent kinases and also inducing protein-protein interactions. This molecule is produced by the adenylate cyclase (AC) enzyme, using ATP as its substrate. Mammalian adenylate cyclase has nine closely related membrane-bound isoforms (AC1-9) showing significant sequence homology and sharing the same overall structure: two hydrophobic transmembrane domains, and two cytoplasmic domains that are responsible for the catalytic activity. These isoforms differ in both their tissue specificity and their regulation. Regulatory factors known to influence one or more of these isoforms include G proteins, protein kinases, calcium and calmodulin [PMID: 11264454, PMID: 12940771].

GO terms

Biological Process

GO:0006171 cAMP biosynthetic process

Molecular Function

GO:0004016 adenylate cyclase activity

Cellular Component

GO:0005886 plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.