NEDD8-activating enzyme E1 regulatory subunit APP-BP1 (IPR030667)

Short name: APP-BP1

Overlapping homologous superfamilies

Family relationships



APP-BP1 (beta-Amyloid precursor protein binding protein 1), also known as Ula1 in yeasts, is a regulatory subunit of the E1 enzyme. Human APP-BP1 is necessary for cell cycle progression through the S-M checkpoint [PMID: 10722740]. Drosophila APP-BP1 interacts antagonistically with APPL (APP-like protein) during Drosophila development [PMID: 16628230].

Ubiquitin-like proteins (ublps) are conjugated to their targets by the sequential action of E1, E2 and often E3 enzymes. Each Ublp has a dedicated E1, or activating enzyme, that initiates its conjugation cascade. In humans the NEDD8 activating E1 enzyme is a heterodimer composed of APP-BP1 and UBA3 subunits. The ubiquitin-like protein (Ublp) NEDD8 regulates cell division, signalling and embryogenesis [PMID: 12646924].

GO terms

Biological Process

GO:0045116 protein neddylation

Molecular Function

GO:0019781 NEDD8 activating enzyme activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.