Family

Galectin-7 (IPR030640)

Short name: Galectin_7

Family relationships

None.

Description

Animal lectins are proteins that bind to sugars and are involved in most non-structural roles of sugars, including trafficking of glycoconjugates and cell-cell recognition. Although they may be structurally very complex, they typically bind through the activity of a specific compact protein domain known as a carbohydrate-binding domain or CRD [PMID: 9787635]. Animal lectins display a wide variety of architectures, and are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type.

Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals [PMID: 8124704]. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction. Mammalian galectins typically bind beta-galactosides. Their CRD shows a structural similarity to L-type lectin CRDs, but no strong sequence similarity, suggesting convergent evolution [PMID: 8262940]. They are classified into three subgroups: proto type, which contain one CRD (Gal-1, -2, -5, -7, -10, -11, -13, -14 and -15); tandem repeat type, which contain two CRDs in tandem (Gal-4, -6, -8, -9 and -12); and chimera type, which contain one CRD and an additional non-lectin domain (Gal-3) [PMID: 8400545, PMID: 14758066].

Galectin-7 could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. It is involved in the migration of epithelial cells and re-epithelisation of corneal and/or epidermal wounds [PMID: 12523890]. It is a pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release [PMID: 11706006]. Gal-7 is a proto-type galectin and is known to dimerise in solution [PMID: 9760227, PMID: 21898049].

GO terms

Biological Process

GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

Molecular Function

GO:0030246 carbohydrate binding

Cellular Component

GO:0005615 extracellular space

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER