Galectin-8 (IPR030638)

Short name: Galectin_8

Overlapping homologous superfamilies


Family relationships



Animal lectins are proteins that bind to sugars and are involved in most non-structural roles of sugars, including trafficking of glycoconjugates and cell-cell recognition. Although they may be structurally very complex, they typically bind through the activity of a specific compact protein domain known as a carbohydrate-binding domain or CRD [PMID: 9787635]. Animal lectins display a wide variety of architectures, and are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type.

Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals [PMID: 8124704]. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction. Mammalian galectins typically bind beta-galactosides. Their CRD shows a structural similarity to L-type lectin CRDs, but no strong sequence similarity, suggesting convergent evolution [PMID: 8262940]. They are classified into three subgroups: proto type, which contain one CRD (Gal-1, -2, -5, -7, -10, -11, -13, -14 and -15); tandem repeat type, which contain two CRDs in tandem (Gal-4, -6, -8, -9 and -12); and chimera type, which contain one CRD and an additional non-lectin domain (Gal-3) [PMID: 8400545, PMID: 14758066].

Galectin-8 has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans [PMID: 21288902]. Galectin-8 is a tandem-repeat type galectin [PMID: 11494049] which interacts with cell surface glycoproteins, including integrins [PMID: 10852818], as well as with extracellular matrix molecules such as fibronectin [PMID: 11371555]. It is an essential molecule in the extracellular matrix and an important component of the angiogenesis network [PMID: 24939370, PMID: 14758075]. This lectin orchestrates the interaction between leukocytes, platelets and endothelial cells [PMID: 24957054].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0030246 carbohydrate binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.