FYN-binding protein (IPR030635)

Short name: FYB

Overlapping homologous superfamilies


Family relationships



FYN-binding protein (FYB), also known as ADAP or SLAP, is an adapter protein in beta 1 integrin signalling and T lymphocyte migration [PMID: 10640723]. It has been found to co-localise with F-actin in membrane ruffles, adhesion plaques/podosomes and phagocytic cups [PMID: 11553777, PMID: 11739662]. In activated T cells, Fyb/SLAP associates with Ena/VASP family proteins and may link T cell signalling to the actin cytoskeleton remodelling [PMID: 10747096]. FYB also interacts with mammalian actin binding protein 1 (mAbp1) that affects F-actin dynamics [PMID: 15848169].

GO terms

Biological Process

GO:0006955 immune response

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0015629 actin cytoskeleton

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.