Regulating synaptic membrane exocytosis protein 2 (IPR030631)

Short name: RIM2

Overlapping homologous superfamilies


Family relationships



The active zone is the presynaptic region in the nerve terminals that mediates neurotransmitter release and is composed a dense collection of proteins called the cytomatrix at the active zone (CAZ). The CAZ proteins are thought to mediate synapse formation and regulate neurotransmitter release [PMID: 22933801, PMID: 24348337].

RIM proteins are scaffolding proteins at the active zone which bind to several other presynaptic proteins. The long isoforms of RIM proteins, which contain N-terminal Rab3 and Munc13 interacting domains, as well as a central PDZ domain and two C-terminal C2 domains, are encoded by two genes, Rim1 and Rim2 [PMID: 25343783]. They have multiple isoforms (alpha, beta, gamma) diverging in their structural composition, which mediate overlapping and distinct functions [PMID: 20370319, PMID: 17124501]. These isoforms are involved in determining Ca2+ channel density and vesicle docking at the presynaptic active zone [PMID: 21262468].

This entry represents regulating synaptic membrane exocytosis protein 2 (RIM2). RIM2alpha plays a critical role in insulin granule exocytosis [PMID: 20674857].

GO terms

Biological Process

GO:0048791 calcium ion-regulated exocytosis of neurotransmitter
GO:0017157 regulation of exocytosis

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0048786 presynaptic active zone

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.