Dihydropyrimidinase-related protein 3 (IPR030628)

Short name: DRP3

Overlapping homologous superfamilies

Family relationships


The Dihydropyrimidinase Related Protein (DRP) family, also known as collapsin response mediator proteins (CRMPs), consists of five members, DRP1-5. Members of this family have been proposed to be part of the semaphorins signal transduction pathway involved in neurite outgrowth, and neuronal differentiation and death [PMID: 11085871, PMID: 23443259]. They are cytosolic proteins highly expressed throughout brain development [PMID: 14514985].

Dihydropyrimidinase-related protein 3 (DRP3), also known as CRMP4 or ULIP1, regulates F-actin bundling, which may by be relevant for growth cone collapse. [PMID: 16181627]. CRMP4 regulates neurite outgrowth, with a critical role in neurite outgrowth inhibition, and associates with vesicles in the growth cone [PMID: 12684468, PMID: 17301178]. Sciatic nerve injury induces the expression of CRMP4 [PMID: 20800647].

GO terms

Biological Process

GO:0051017 actin filament bundle assembly
GO:0051491 positive regulation of filopodium assembly
GO:0030334 regulation of cell migration
GO:0010975 regulation of neuron projection development
GO:0048678 response to axon injury

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.