ERC protein 2 (IPR030625)

Short name: ERC2

Overlapping homologous superfamilies


Family relationships


The active zone is the presynaptic region in the nerve terminals that mediates neurotransmitter release and is composed a dense collection of proteins called the cytomatrix at the active zone (CAZ). The CAZ proteins are thought to mediate synapse formation and regulate neurotransmitter release [PMID: 22933801, PMID: 24348337].

ERC protein 2 (ERC2) forms a protein complex with the other active zone proteins ELKS, Bassoon, Piccolo, RIM1 and Munc13-1, and is thought to play an organisational and functional role in neurotransmitter release. It also interacts with voltage-dependent Ca(2+) channels (VDCCs), which are essential for regulating neurotransmitter release triggered by depolarization-induced Ca(2+) influx at the active zone [PMID: 22577167].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0048786 presynaptic active zone

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.