Dihydropyrimidinase-related protein 2 (IPR030615)

Short name: DRP2

Overlapping homologous superfamilies

Family relationships


The Dihydropyrimidinase Related Protein (DRP) family, also known as collapsin response mediator proteins (CRMPs), consists of five members, DRP1-5. Members of this family have been proposed to be part of the semaphorins signal transduction pathway involved in neurite outgrowth, and neuronal differentiation and death [PMID: 11085871, PMID: 23443259]. They are cytosolic proteins highly expressed throughout brain development [PMID: 14514985].

Dihydropyrimidinase-related protein 2 (DRP2), also known as CRMP2 or ULIP2, mediates axonogenesis, axon outgrowth and neuronal polarity, as well as migration [PMID: 11477421, PMID: 14598368, PMID: 12942088, PMID: 11477421]. DRP2/CRMP2 modulates neurite length through direct binding to tubulin and promoting microtubule polymerisation [PMID: 10770920, PMID: 12134159, PMID: 19666111]. It interacts with numerous binding partners to affect microtubule dynamics, endocytosis, synaptic assembly, calcium channel regulation and neurotransmitter release [PMID: 20801876, PMID: 21271304, PMID: 23308041].

DRP2/CRMP2 is expressed widely in neuronal tissues, and is also expressed in non-neuronal cells, including fibroblasts [PMID: 16414354] and T-cells [PMID: 16301675, PMID: 18006081], which suggests roles in proliferation and immune function. Two variants of CRMP2 have been reported, a long and short form, with a common core polypeptide but different N-terminal domains that are products of alternative mRNA splicing [PMID: 22431514]. The balance between the expression of the two subtypes is involved in the control of axonal branching and elongation.

GO terms

Biological Process

GO:0007411 axon guidance
GO:0007420 brain development
GO:0007010 cytoskeleton organization
GO:0030516 regulation of axon extension
GO:0045664 regulation of neuron differentiation

Molecular Function

GO:0008017 microtubule binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.