Aurora kinase C (IPR030613)
Short name: AURKC
Overlapping homologous superfamilies
- Protein kinase-like domain superfamily (IPR011009)
- Aurora kinase (IPR030616)
- Aurora kinase C (IPR030613)
Aurora kinase C (AURKC) is a serine/threonine-protein kinase found in some mammals. It is a component of the chromosomal passenger protein that forms complexes with Aurora-B and inner centromere protein (INCENP), and it has redundant cellular functions with AURKB [PMID: 15316025]. It is required for spermatogenesis and oocyte development [PMID: 24632603, PMID: 17192404]. The overexpression of AURKC has been linked to various cancers [PMID: 23581231]. Overexpression of Aurora-C displaces the centromeric localisation of chromosomal passenger complex (CPC) proteins, including Aurora-B [PMID: 24603334]. CPC plays a crucial role in controlling accurate chromosome segregation and cytokinesis during cell division.
The Aurora kinases are highly conserved serine/threonine kinases that regulate chromosomal alignment and segregation during mitosis and meiosis. Three mammalian Aurora kinases, Aurora A, B and C, have been identified. They all contain a protein kinase domain and a destruction box (D-box) recognised by the multi-subunit E3-ubiquitin ligase anaphase promoting complex/cyclosome (APC/C), which mediates their proteasomal degradation. However, their N-terminal domain share little sequence identity and confer unique protein-protein interaction abilities among the Aurora kinases [PMID: 14625535]. They are differentially expressed at high levels in rapidly dividing tissues such as hematopoietic cells (A and B) and germ cells (C only). Their expression is low or absent in most adult tissues due to their lower rates of proliferation [PMID: 24632603].
- PTHR24350:SF3 (PTHR24350:SF3)