C-C motif chemokine 22 (IPR030598)

Short name: CCL22

Overlapping homologous superfamilies

Family relationships



Macrophage-derived chemokine or CC chemokine 22 (MDC/CCL22) is a chemokine produced by macrophages and dendritic cells [PMID: 11241286]. It is a chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells [PMID: 9151897]. It binds to receptor CCR4 [PMID: 10985257, PMID: 9430724]. MDC/CCL2 may play an important role in the recruitment of TH2 cells into the inflammatory sites and the regulation of T helper type 2 (TH2)-related immune responses [PMID: 12433129, PMID: 22125604].

GO terms

Biological Process

GO:0060326 cell chemotaxis
GO:0006954 inflammatory response

Molecular Function

GO:0008009 chemokine activity

Cellular Component

GO:0005615 extracellular space

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.