Kelch-like protein 17 (IPR030594)

Short name: KLHL17

Overlapping homologous superfamilies


Family relationships


Kelch-like protein 17 (KLHL17, also known as actinfilin) belongs to the KLHL family [PMID: 23676014]. It binds to the actin cytoskeleton and serves as a substrate-specific adapter in the Cul3-dependent ubiquitin ligase complex that targets GluR6 kainate receptor subunit for degradation [PMID: 17062563]. Kainate receptors (KAR) are ionotropic receptors that respond to the neurotransmitter glutamate and have been implicated in epilepsy, stroke, Alzheimer's and neuropathic pain [PMID: 21713671].

The KLHL (Kelch-like) proteins generally have a BTB/POZ domain, a BACK domain, and five to six Kelch motifs. They constitute a subgroup at the intersection between the BTB/POZ domain and Kelch domain superfamilies. The BTB/POZ domain facilitates protein binding [PMID: 23676014], while the Kelch domain (repeats) form beta-propellers. The Kelch superfamily of proteins can be subdivided into five groups: (1) N-propeller, C-dimer proteins, (2) N-propeller proteins, (3) propeller proteins, (4) N-dimer, C-propeller proteins, and (5) C-propeller proteins. KLHL family members belong to the N-dimer, C-propeller subclass of Kelch repeat proteins [PMID: 10603472]. In addition to BTB/POZ and Kelch domains, the KLHL family members contain a BACK domain, first described as a 130-residue region of conservation observed amongst BTB-Kelch proteins [PMID: 15544948]. Many of the Kelch-like proteins have been identified as adaptors for the recruitment of substrates to Cul3-based E3 ubiquitin ligases [PMID: 23135275, PMID: 14528312].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.