C-C motif chemokine 21 (IPR030593)

Short name: CCL21

Overlapping homologous superfamilies

Family relationships



CC chemokine 21 (CCL21), also known as secondary lymphoid-organ chemokine (SLC), is a ligand for the chemokine receptor CCR7 [PMID: 23587803]. CCL19 and CCL21 are the only ligands for CCR7, which is expressed by various subsets of immune cells. CCL19 and CCL21 function to recruit CCR7 expressing antigen presenting cells, like dendritic cells and naive T-cells, to the lymph nodes [PMID: 17891505, PMID: 18379575]. CCL21 seems to be the critical CCR7 ligand regulating dendritic cell homeostasis and function [PMID: 20201039].

CCL21 has an unusual extended C-terminal tail for a chemokine [PMID: 9235955]. Only one gene exists for this chemokine in human beings, whereas mice have two [PMID: 10523616].

GO terms

Biological Process

GO:0060326 cell chemotaxis

Molecular Function

GO:0031732 CCR7 chemokine receptor binding
GO:0008009 chemokine activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.