Family

Myotubularin-related protein 7 (IPR030572)

Short name: MTMR7

Family relationships

Description

Myotubularin-related protein 7 (MTMR7) is a member of the myotubularin (MTM) family. MTMR9 is a binding partner of MTMR7, and binding of MTMR9 increases the phosphatase activity of MTMR7 [PMID: 12890864]. MTMR9 and MTMR7 may be involved in regulating T-helper (Th) cells differentiation [PMID: 23630283].

The myotubularin family constitutes a large group of conserved proteins, with 14 members in humans consisting of myotubularin (MTM1) and 13 myotubularin-related proteins (MTMR1-MTMR13). Orthologues have been found throughout the eukaryotic kingdom, but not in bacteria. MTM1 dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) to phosphatidylinositol and phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2] to phosphatidylinositol 5-monophosphate (PI5P) [PMID: 10900271, PMID: 11001925]. The substrate phosphoinositides (PIs) are known to regulate traffic within the endosomal-lysosomal pathway [PMID: 16828287]. MTMR1, MTMR2, MTMR3, MTMR4, and MTMR6 have also been shown to utilise PI(3)P as a substrate, suggesting that this activity is intrinsic to all active family members. On the other hand, six of the MTM family members encode for catalytically inactive phosphatases. Inactive myotubularin phosphatases contain substitutions in the Cys and Arg residues of the Cys-X5-Arg motif. MTM pseudophosphatases have been found to interact with MTM catalytic phosphatases [PMID: 16787938]. The myotubularin family includes several members mutated in neuromuscular diseases or associated with metabolic syndrome, obesity, and cancer [PMID: 22578719].

GO terms

Biological Process

GO:0046856 phosphatidylinositol dephosphorylation

Molecular Function

GO:0052866 phosphatidylinositol phosphate phosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER