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Overview
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Structures
DNA polymerase zeta catalytic subunit (IPR030559)
Short name: PolZ_Rev3
Overlapping homologous superfamilies
None.
Family relationships
None.
Description
DNA polymerase zeta (Pol zeta) belongs to the B-family of polymerases. It is a nonessential DNA polymerase responsible for the majority of damage-induced mutagenesis in eukaryotes [PMID: 2676986]. It is involved in double-strand breaks DNA repair [PMID: 9383049] and has a major role in translesion DNA synthesis (TLS) , an alternative DNA damage tolerance mechanism that allows the DNA replication machinery to replicate past DNA lesions [PMID: 11356151, PMID: 15588843]. Pol zeta lacks proofreading activity and its discrimination against insertion of incorrect bases is lower than that of other B-family polymerases [PMID: 16971464]. Discrimination against ribonucleotide incorporation is only slightly lower than in the case of the replicative DNA polymerases [PMID: 24674899].
Originally discovered in budding yeast, genes encoding this enzyme have been found in all fully sequenced eukaryotic genomes [PMID: 12509231]. Its role in translesion replication is probably the most widespread [PMID: 24449906].
GO terms
Biological Process
GO:0006281 DNA repair
GO:0019985 translesion synthesis
Molecular Function
No terms assigned in this category.
Cellular Component
GO:0016035 zeta DNA polymerase complex
Contributing signatures
- PTHR10322:SF5 (PTHR10322:SF5)
- PTHR10322:SF26 (PTHR10322:SF26)