DNA polymerase zeta catalytic subunit (IPR030559)

Short name: PolZ_Rev3

Overlapping homologous superfamilies


Family relationships



DNA polymerase zeta (Pol zeta) belongs to the B-family of polymerases. It is a nonessential DNA polymerase responsible for the majority of damage-induced mutagenesis in eukaryotes [PMID: 2676986]. It is involved in double-strand breaks DNA repair [PMID: 9383049] and has a major role in translesion DNA synthesis (TLS) , an alternative DNA damage tolerance mechanism that allows the DNA replication machinery to replicate past DNA lesions [PMID: 11356151, PMID: 15588843]. Pol zeta lacks proofreading activity and its discrimination against insertion of incorrect bases is lower than that of other B-family polymerases [PMID: 16971464]. Discrimination against ribonucleotide incorporation is only slightly lower than in the case of the replicative DNA polymerases [PMID: 24674899].

Originally discovered in budding yeast, genes encoding this enzyme have been found in all fully sequenced eukaryotic genomes [PMID: 12509231]. Its role in translesion replication is probably the most widespread [PMID: 24449906].

GO terms

Biological Process

GO:0006281 DNA repair
GO:0019985 translesion synthesis

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016035 zeta DNA polymerase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.