Family

DNA repair protein XRCC2 (IPR030547)

Short name: XRCC2

Family relationships

None.

Description

DNA repair protein XRCC2 is a RAD51 paralogue. In humans, it is part of the protein complex BCDX2 (contains RAD51B, RAD51C, RAD51D, and XRCC2), which acts in the BRCA1-BRCA2-dependent homologous recombination pathway [PMID: 11751635, PMID: 23149936]. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA [PMID: 11751635]. Interestingly, XRCC2 and other homologous recombination proteins are associated with centrosomes and are required for mitotic stability [PMID: 21276791].

GO terms

Biological Process

GO:0006281 DNA repair
GO:0000724 double-strand break repair via homologous recombination

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex
GO:0005657 replication fork

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER