Family

Clathrin interactor 1 (IPR030544)

Short name: CLINT1

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Clathrin interactor 1 (CLINT1, also known as EpsinR) promotes Clathrin-coated vesicle formation at the trans-Golgi network and endosomes and thereby modulates Golgi-endosome trafficking [PMID: 23029494]. It binds to the SNARE Protein vti1b [PMID: 15371541]. Interestingly, one isoform of Drosophila EpsinR is a translational fusion with the only Tel2 coding sequences in Drosophila. In this fusion protein, Tel2 serves as a regulator of wingless signalling [PMID: 23029494]. Human EpsinR is involved in endogenous MHC-II-restricted antigen presentation [PMID: 25196058].

GO terms

Biological Process

GO:0016192 vesicle-mediated transport

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005794 Golgi apparatus
GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER