Family

Amyloid beta A4 precursor protein-binding family A member 2 (IPR030529)

Short name: Apba2

Family relationships

None.

Description

Amyloid beta A4 precursor protein-binding family A member 2, also known as Mint2, X11beta, or X11L, is a neuronal adaptor protein that binds to the intracellular domain of the amyloid precursor protein (APP) [PMID: 19744962]. It belongs to the X11/Mint family of adaptor proteins [PMID: 16764936]. It has been shown to modulate processing of APP and accumulation of Abeta (hallmark pathologies of Alzheimer's disease), making it a potential therapeutic target for Alzheimer's disease [PMID: 16764936, PMID: 19744962]. X11beta, as X11alpha, is a important regulator of presynaptic neurotransmitter release [PMID: 17167098].

The X11/Mint family members are multidomain proteins typically composed of a conserved PTB domain and two C-terminal PDZ domains. They are adaptor proteins that possess several functions, such as trafficking and transport, synaptic function and regulation of ion channel [PMID: 16764936]. Two of the family members, X11alpha and X11beta, are expressed primarily in neurones [PMID: 16764936].

GO terms

Biological Process

GO:0007268 chemical synaptic transmission

Molecular Function

GO:0001540 amyloid-beta binding

Cellular Component

GO:0008021 synaptic vesicle

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER