SH2B adapter protein 1 (IPR030521)

Short name: SH2B1

Overlapping homologous superfamilies


Family relationships


SH2B adapter protein 1 (SH2B1) belongs to the SH2B family of adapter proteins [PMID: 11498022]. It promotes insulin expression and glucose metabolism in beta-cells in mice [PMID: 24645678]. It is also involved in brain-derived neurotrophic factor-induced neurite outgrowth [PMID: 24260264].

SH2B family contains three members of adaptor proteins: SH2B1, 2 and 3 [PMID: 17140804]. Typical SH2B proteins contain a SH2 (Src homology 2) and a PH (pleckstrin homology) domain. They serve as adaptors involved in signalling by the receptors for growth factors, such as insulin-like growth factor 1, platelet-derived growth factor and nerve growth factor [PMID: 11498022].

GO terms

Biological Process

GO:0007165 signal transduction

Molecular Function

GO:0035591 signaling adaptor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.