SH2B adapter protein 2 (IPR030520)

Short name: SH2B2

Overlapping homologous superfamilies


Family relationships


SH2B adapter protein 2 (SH2B2, also known as APS) belongs to the SH2B family of adapter proteins [PMID: 11498022]. SH2B2 is involved in multiple signalling pathways, including cytokine signalling and insulin receptor signalling [PMID: 9989826, PMID: 17140804]. It also binds to Vav3, a member of the vav proto-oncogene family, and increases its activity [PMID: 12400014].

SH2B family contains three members of adaptor proteins: SH2B1, 2 and 3 [PMID: 17140804]. Typical SH2B proteins contain a SH2 (Src homology 2) and a PH (pleckstrin homology) domain. They serve as adaptors involved in signalling by the receptors for growth factors, such as insulin-like growth factor 1, platelet-derived growth factor and nerve growth factor [PMID: 11498022].

GO terms

Biological Process

GO:0007165 signal transduction

Molecular Function

GO:0035591 signaling adaptor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.