Tetratricopeptide repeat protein 26 (IPR030511)

Short name: TTC26

Overlapping homologous superfamilies


Family relationships



This entry refers to Tetratricopeptide repeat protein 26 (TTC26, also known as Intraflagellar transport protein 56).

TTC26 is required for ciliogenesis and normal cilia function in zebrafish [PMID: 22718903]. A mutation in the mouse TTC26 gene leads to impaired hedgehog signalling and causes hop-sterile (hop), which is characterised by a hopping gait, polydactyly, hydrocephalus, and male sterility [PMID: 25340710]. Mouse TTC26 binds directly to the Ift46 subunit of Intraflagellar Transport (IFT) complex B, however, the TTC26 defect does not result in a decrease in the number or length of primary cilia [PMID: 25340710].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.