Proto-oncogene c-Rel (IPR030505)

Short name: c-Rel

Overlapping homologous superfamilies


Family relationships


NF-kappaB is a pleiotropic transcription factor present in almost all cell types. It is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappaB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RelA/p65, RelB, NFKB1/p50, c-Rel and NFKB2/p52 [PMID: 22302935]. Each individual NF-kappaB subunit, and perhaps each dimer, carries out unique functions in regulating transcription. Dimer-specific functions can be conferred by selective protein-protein interactions with other transcription factors, coregulatory proteins, and chromatin proteins [PMID: 22435556].

c-Rel plays a role in B-cell proliferation and survival. It is considered a proto-oncogene. c-Rel has been shown to be able to malignantly transform cultured cells, and amplifications of human c-rel are frequently seen in lymphomas [PMID: 14755244].

GO terms

Biological Process

GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0045893 positive regulation of transcription, DNA-templated

Molecular Function

GO:0003700 DNA binding transcription factor activity

Cellular Component

GO:0005737 cytoplasm
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.