Purine-rich element-binding protein alpha (IPR030500)

Short name: PURalpha

Overlapping homologous superfamilies


Family relationships


Transcriptional activator protein PURalpha (also known as purine-rich element-binding protein alpha) belongs to the purine-rich element binding (PUR) protein family, which consists of PURalpha, PURbeta and PURgamma. PURalpha and PURbeta are single-stranded DNA-binding proteins that play a role in cell growth and differentiation by modulating both transcriptional and translational controls of gene expression [PMID: 17612644]. They are linked to the repression of genes such as smooth muscle alpha-actin (SMalphaA), alpha-myosin heavy chain, and beta-myosin heavy chain [PMID: 12933792, PMID: 19496623]. PURalpha also binds to RNA and has been shown to influence the HIV-1 and JC virus (JCV) interaction in AIDS [PMID: 12894583]. In mice it is critical for postnatal brain development and plays a role in DNA repair [PMID: 19182532].

GO terms

Biological Process

GO:0030154 cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0042127 regulation of cell proliferation

Molecular Function

GO:0003700 DNA-binding transcription factor activity
GO:0003723 RNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.