Pathways & interactions
Purine-rich element-binding protein alpha (IPR030500)
Short name: PURalpha
Overlapping homologous superfamilies
- Purine-rich element binding protein family (IPR006628)
- Purine-rich element-binding protein alpha (IPR030500)
Transcriptional activator protein PURalpha (also known as purine-rich element-binding protein alpha) belongs to the purine-rich element binding (PUR) protein family, which consists of PURalpha, PURbeta and PURgamma. PURalpha and PURbeta are single-stranded DNA-binding proteins that play a role in cell growth and differentiation by modulating both transcriptional and translational controls of gene expression [PMID: 17612644]. They are linked to the repression of genes such as smooth muscle alpha-actin (SMalphaA), alpha-myosin heavy chain, and beta-myosin heavy chain [PMID: 12933792, PMID: 19496623]. PURalpha also binds to RNA and has been shown to influence the HIV-1 and JC virus (JCV) interaction in AIDS [PMID: 12894583]. In mice it is critical for postnatal brain development and plays a role in DNA repair [PMID: 19182532].
No terms assigned in this category.
- PTHR12611:SF2 (PTHR12611:SF2)