Transcription factor RelB (IPR030496)

Short name: RelB

Overlapping homologous superfamilies


Family relationships


RelB is a component of the NF-kappa-B RelB-p50 complex and the RelB-p52 complex [PMID: 17869269]. It is best known for its roles in lymphoid development and noncanonical signalling [PMID: 19302050], but it seems to be linked to many distinct processes. Among others, RelB may have a role in suppressing inflammation [PMID: 25409035] and has been shown to negatively regulate osteoblast differentiation and bone formation [PMID: 24115294].

NF-kappaB is a pleiotropic transcription factor present in almost all cell types. It is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappaB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RelA/p65, RelB, NFKB1/p50, c-Rel and NFKB2/p52 [PMID: 22302935]. Each individual NF-kappaB subunit, and perhaps each dimer, carries out unique functions in regulating transcription. Dimer-specific functions can be conferred by selective protein-protein interactions with other transcription factors, coregulatory proteins, and chromatin proteins [PMID: 22435556].

GO terms

Biological Process

GO:0006357 regulation of transcription by RNA polymerase II

Molecular Function

GO:0003700 DNA binding transcription factor activity

Cellular Component

GO:0005737 cytoplasm
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.