Pathways & interactions
Short name: Shrm3
Overlapping homologous superfamilies
- Shroom family (IPR027685)
- Shroom3 (IPR030494)
Protein Shroom3 (Shrm3) belongs to the Shroom family, whose members are linked to the actin cytoskeleton [PMID: 16684770]. Shrm3 is an actin binding protein that directs Rho kinase- and RhoA-dependent apical constriction in the lens placode and partially facilitates invagination [PMID: 10589677, PMID: 20081189, PMID: 22031541, PMID: 25038041]. It is recruited to adherens junctions by cadherin-binding ZA (zonula adherens) protein p120-catenin during lens pit morphogenesis [PMID: 25038041]. It is necessary for neural tube closure in vertebrate development [PMID: 18339671, PMID: 24282618].
- PTHR15012:SF33 (PTHR15012:SF33)