Shroom3 (IPR030494)

Short name: Shrm3

Overlapping homologous superfamilies


Family relationships


Protein Shroom3 (Shrm3) belongs to the Shroom family, whose members are linked to the actin cytoskeleton [PMID: 16684770]. Shrm3 is an actin binding protein that directs Rho kinase- and RhoA-dependent apical constriction in the lens placode and partially facilitates invagination [PMID: 10589677, PMID: 20081189, PMID: 22031541, PMID: 25038041]. It is recruited to adherens junctions by cadherin-binding ZA (zonula adherens) protein p120-catenin during lens pit morphogenesis [PMID: 25038041]. It is necessary for neural tube closure in vertebrate development [PMID: 18339671, PMID: 24282618].

GO terms

Biological Process

GO:0000902 cell morphogenesis
GO:0002064 epithelial cell development
GO:0001843 neural tube closure

Molecular Function

GO:0003779 actin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.